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Desyrel (Trazodone) is primarily used for the treatment of depression.

Drug Name

Desyrel (Trazodone)

Drug Uses

Trazodone is primarily used for the treatment of depression; however, it is sometimes prescribed as a sedative, and it also is used in combination with other drugs for the treatment of psychiatric conditions other than depression and cocaine withdrawal.

How Taken

For the treatment of depression, the dose for adults is 150-600 mg per day. The initial starting dose usually is 150 mg per day. Trazodone is given in one or more daily doses, sometimes with the largest dose at night. As with all antidepressants, it may take several weeks for the full effects of treatment to be seen. Doses often are adjusted slowly upwards to find the optimal dose. Elderly patients and debilitated persons may need lower doses. Trazodone should be taken after a meal or light snack to reduce the risk of dizziness. Food also increases the amount of drug absorbed into the body.

Drug Class and Mechanism

Trazodone is an oral antidepressant drug that affects the chemical messengers (neurotransmitters) within the brain that nerves use to communicate with (stimulate) each other. The major neurotransmitters are acetylcholine, norepinephrine, dopamine and serotonin. Many experts believe that an imbalance among the different neurotransmitters is the cause of depression. Although the exact mechanism of action of trazodone is unknown, it probably improves symptoms of depression by inhibiting the uptake of serotonin by nerves in the brain. This results in more serotonin to stimulate other nerves. Trazodone also may increase directly the action of serotonin. Trazodone is chemically unrelated to the serotonin reuptake inhibitors (SSRIs), the tricyclic antidepressants (TCAs) or the monoamine oxidase inhibitors (MAO inhibitors). It is chemically related to nefazodone (Serzone) and shares its actions. Trazodone was approved by the Food and Drug Administration in 1982.

Missed Dose

Take the missed dose as soon as you remember. However, if it is almost time for the next regularly scheduled dose, skip the missed dose and take only the next one as directed. Do not take a double dose of this medication.


Store at room temperature, 15-30 degrees C (59-86 degrees F)